I saw this a few days ago on MyHeritage – What Does a Polygenic Risk Score Mean? – MyHeritage DNA Saturdays January 11, 2020 https://blog.myheritage.com/2020/01/what-does-a-polygenic-risk-score-mean/. I thought it would make a good DNA Saturdays post.
by Jessica Greenwood, MS, LGC January 8, 2020
Last month we announced that the MyHeritage DNA Health test includes a fourth polygenic risk report for high blood pressure in addition to its initial 3 polygenic risk reports for type 2 diabetes, heart disease, and female breast cancer. In the first Health Basics post, we explored what a polygenic risk score actually is. In this post, we’ll dig further into what they mean and how they can be applied to your health.
Polygenic risk score (PRS) is a newer development in the world of genetic testing that is now being applied to health. We’ve known that chronic conditions like obesity and heart disease run in families, but prior to the application of PRS to health, we were limited in the ability to determine a person’s genetic risk for these conditions. PRS provides an estimate of the genetic risk to develop certain chronic conditions by looking at variants at many locations across the genome and combining their contributions into a single risk score. This score is calculated by a mathematical model that includes the variants found in the DNA sample you submit and the impact each of those variants has on disease risk.
Previous DNA Saturdays posts: Other DNA Saturdays posts: https://upsdownsfamilyhistory.wordpress.com/tag/DNA-Saturdays/